CoVIC ID Antibody features Affinity, KD (M) - Duke Pseudovirus neutralization (ng/mL) Pseudovirus neutralization - Beta (ng/mL) Pseudovirus neutralization - Delta (ng/mL) Authentic virus neutralization (ng/mL) - UNC Authentic virus neutralization (ng/mL) - UTMB In vivo protection survival (%) Fc Activity - Ragon Complex formation inhibition (%) Antibody dependent enhancement sequence / structural features Details
Isotype Epitope Community (RBD) D614 D614G RBD NTD B.1.351 IC50- Pseudovirus neutralization (ng/mL) IC80- Pseudovirus neutralization (ng/mL) IC90- Pseudovirus neutralization (ng/mL) IC50- Pseudovirus neutralization (ng/mL) IC80- Pseudovirus neutralization (ng/mL) IC90- Pseudovirus neutralization (ng/mL) IC50- Pseudovirus neutralization (ng/mL) IC80- Pseudovirus neutralization (ng/mL) IC90- Pseudovirus neutralization (ng/mL) IC50 (WA-1)- Authentic virus neutralization (ng/mL) IC80 (WA-1)- Authentic virus neutralization (ng/mL) IC90 (WA-1)- Authentic virus neutralization (ng/mL) IC50 (B.1.351)- Authentic virus neutralization (ng/mL) IC80 (B.1.351)- Authentic virus neutralization (ng/mL) IC50- UTMB - Authentic virus neutralization (ng/mL) IC80- UTMB - Authentic virus neutralization (ng/mL) IC90- UTMB - Authentic virus neutralization (ng/mL) K18 mice hamsters ADCP mADCP ADNP mADNP ADCD (MFI C3) ADNKA % CD107a+ ADNKA % MIP-1b+ FcgR2aR (MFI) FcgR3aV (MFI) FcgR2b (MFI) FcgR3b (MFI) FcRn (MFI) mFcR2 (MFI) mFcR3 (MFI) mFcR4 (MFI) Spike: ACE2 Score (for level of ADE at 10 ug/mL) IC50 IC80 IC90 Escape Structure
CC12.3 None 5035 16232 39.130434782608695
Untreated Infected Control None 0.0
Mock Infected Control None 98.26086956521739
CR3022 None moderate weak weak moderate weak strong strong 5.99 6.11 4.78 5.73 3.94 5.12 5.3 6.16
KZ52 None weak moderate weak strong weak weak weak 4.06 3.84 4.38 3.7 3.78 3.59 4.4 4.29
negative plasma None weak moderate weak weak strong weak weak 4.01 3.79 4.33 3.7 3.76 3.58 4.33 4.2
CC12.14 None 1299 4989
1 IgG1 3 1.63e-09 1.75e-10 1.46e-06 4.19e-08 1.83 6.37 14.1 2430.0 2510.0 2530.0 202.0 245 662 1.24e+03 1.65e+03 1.95e+03 weak moderate weak strong moderate weak moderate 6.09 6.05 5.48 4.83 3.5 3.93 4.87 5.66 69.6
2 IgG1 2 1.24e-10 5.16e-11 1.23e-07 1.33e-11 1.47 4.01 7.91 20.6 89.3 209.0 19 60 3.03e+02 4.69e+02 6.05e+02 5.0 strong strong strong strong moderate moderate moderate 6.34 6.28 6.01 6.42 5.65 5.96 5.89 6.63 100.0 Y489H
3 IgG1 2 1.47e-09 8.3e-10 8.93e-07 2.32 8.36 16.0 705.0 2850.0 4420.0 846 2766 3.20e+03 6.50e+03 9.84e+03 weak weak weak strong weak moderate moderate 5.87 5.99 5.0 4.39 3.63 3.94 4.68 5.03 90.3
4 IgG1 2 2.43e-10 8.05e-11 1.11e-07 1.84e-08 0.709 2.48 5.02 1530.0 1560.0 1570.0 759.0 5560.0 179 450 1.49e+03 2.73e+03 3.88e+03 moderate weak weak strong weak moderate weak 6.21 6.23 5.66 5.54 4.92 3.95 4.76 5.47 100.0
5 IgG1 2 1.08e-09 8.64e-10 3.98e-07 0.853 2.6 5.26 29.8 186.0 406.0 158.0 415.0 679.0 433 754 1.57e+04 1.84e+04 2.02e+04 weak weak weak moderate weak moderate moderate 6.05 6.08 5.36 5.14 4.56 3.94 4.77 5.14 98.2
6 IgG1 2 5.53e-10 3.53e-10 8.71e-08 5.98e-10 36.3 74.9 118.0 21.4 102.0 249.0 11861 22679 2.52e+02 4.86e+02 7.14e+02 moderate moderate weak weak moderate moderate weak 6.05 5.94 5.65 5.87 4.09 4.59 5.11 5.91 99.0
7 IgG1 6 1.21e-10 3.66e-11 1.72e-08 4.5e-06 4.92e-09 0.0538 0.146 0.261 18 33 2.50e+04 2.50e+04 2.50e+04 moderate moderate moderate moderate weak moderate weak 6.09 6.0 5.71 5.98 4.58 4.57 4.92 6.15 100.0
8 IgG1 6 6.75e-10 4.51e-10 2.36e-08 1.34e-10 12.8 26.0 40.9 2191 6355 1.02e+04 1.13e+04 1.21e+04 moderate weak moderate weak weak moderate weak 6.34 6.28 6.01 6.38 5.35 5.49 5.22 6.41 98.0
9 IgG1 2 1.65e-11 7.06e-12 2.33e-10 9.29e-08 3.63e-11 0.0126 0.024 0.0341 1140.0 1170.0 1170.0 <0.32 0.54 3035 4766 4.83e+00 8.61e+00 1.21e+01 10.0 weak weak weak moderate weak moderate weak 3.75 3.75 3.67 3.72 3.45 3.87 4.18 4.64 100.0
10 IgG1 2 1.84e-11 8.3e-12 2.04e-10 8.55e-08 3.92e-11 0.0101 0.0212 0.0327 464.0 2300.0 7470.0 51.2 325.0 907.0 <0.32 1 5862 15389 1.18e+01 2.19e+01 3.15e+01 10.0 weak weak weak weak weak weak weak 3.78 3.74 3.7 3.71 3.46 3.86 4.26 4.24 100.0
11 IgG1 2 2.35e-11 9.87e-12 2.11e-10 4.67e-08 2.81e-11 0.00609 0.0162 0.028 159.0 656.0 1520.0 <0.32 0.93 137 196 1.78e+01 2.62e+01 3.28e+01 weak moderate weak moderate weak moderate weak 3.86 3.77 3.74 3.69 3.45 3.89 4.09 4.16 99.4
12 IgG1 2 1.11e-11 5.07e-12 1.64e-10 7.55e-08 4.24e-11 0.00748 0.0186 0.0306 990.0 1190.0 1250.0 352.0 1050.0 1450.0 <0.32 <0.32 2526 4536 8.62e+00 1.43e+01 1.93e+01 30.0 weak strong weak strong weak moderate weak 3.67 3.75 3.62 3.71 3.45 3.88 4.14 4.2 100.0
13 IgG1 2 8.95e-12 4.71e-12 1.16e-10 5.11e-08 2.42e-11 0.00607 0.0154 0.0253 71.7 235.0 459.0 19.4 54.8 97.5 <0.32 0.85 159 627 4.75e+00 7.05e+00 8.88e+00 weak weak weak strong weak moderate moderate 4.04 4.43 3.8 3.72 3.48 3.91 4.82 4.76 100.0
14 IgG1 2 4.43e-11 1.1e-11 1.94e-09 1.14e-06 5.3e-11 0.00975 0.0247 0.0429 373.0 1490.0 7440.0 <0.32 <0.32 >12500 >12500 6.70e-01 1.42e+00 2.21e+00 strong strong strong strong moderate moderate strong 6.37 6.32 6.02 6.46 5.71 5.99 5.74 6.6 100.0
15 IgG1 2 9.47e-11 4.56e-11 1.19e-08 1.19e-07 1.22e-09 0.032 0.107 0.223 1610.0 3140.0 3780.0 1 10 >12500 >12500 3.12e+01 4.93e+01 6.44e+01 strong strong strong strong strong moderate moderate 6.38 6.33 6.04 6.45 5.74 6.08 5.86 6.63 100.0
16 IgG1 2 1.57e-10 5.04e-11 5.31e-09 1.03e-06 7.34e-10 0.0445 0.18 0.388 995.0 215.0 888.0 1380.0 10518 >25000 1.61e+04 8.58e+04 2.28e+05 moderate weak weak strong weak moderate moderate 6.15 6.15 5.36 3.9 5.09 3.94 4.91 5.04 100.0
17 IgG1 4 5.04e-10 4.01e-10 3.46e-08 1.81e-10 1.03 3.02 5.63 8726 24853 2.50e+04 2.50e+04 2.50e+04 strong moderate moderate moderate moderate moderate moderate 6.33 6.28 5.99 6.4 5.49 5.67 5.66 6.51 67.0
18 IgG
19 IgG 1.08e-09 1.18e-09 2.64e-08 0.0397 0.14 0.262 664.0 433 1516 2.50e+04 2.50e+04 2.50e+04 weak weak weak moderate weak moderate weak 4.07 3.8 3.83 3.73 3.45 3.93 4.75 4.54 23.7
20 IgG1 7.59e-10 8.13e-10 8.15e-08 1.36e-09 0.0723 0.587 639.0 1160.0 1350.0 236 4924 2.59e+03 9.47e+03 2.02e+04 0.0 strong moderate moderate strong strong moderate strong 6.09 6.0 5.77 6.02 4.23 4.57 5.23 6.07 9.0
21 IgG1 7 5.02e-10 1.4e-09 2.08e-10 5.25e-10 12.5 46.6 100.0 162.0 8582 20807 1.99e+04 3.48e+04 4.82e+04 0.0 strong moderate moderate moderate moderate moderate weak 6.29 6.22 5.95 6.3 5.2 5.14 5.34 6.28 11.6
22 IgG1 6 1.08e-09 3e-09 1.04e-07 3.68e-10 128.0 379.0 648.0 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 strong weak moderate weak weak moderate weak 6.24 6.2 5.89 6.22 5.0 4.63 5.2 6.11 51.1
23 IgG1 5 3.72e-10 5.86e-10 7.13e-08 2e-10 14.2 52.1 105.0 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 strong moderate moderate weak moderate moderate weak 6.27 6.22 5.93 6.27 4.82 5.04 5.09 6.27 36.3
24 IgG1 7 1.21e-09 2.3e-09 1.46e-08 7.49e-10 142.0 14175 >25000 2.50e+04 2.50e+04 2.50e+04 moderate strong weak weak weak strong moderate 6.22 6.18 5.86 6.23 5.08 4.78 5.17 6.21 48.7
25 IgG1 7 1.07e-09 1.9e-09 8.49e-08 6.96e-09 324.0 687.0 829.0 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 moderate moderate strong moderate weak moderate moderate 5.77 5.93 5.07 5.59 3.78 4.02 4.91 5.71 31.2
26 IgG1 7 6.57e-10 1.18e-09 3.88e-08 5.36e-09 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 strong weak moderate strong weak moderate moderate 6.22 6.14 5.81 6.16 4.75 4.54 5.25 6.14 31.8
27 IgG1 3 3.59e-09 1.42e-09 1.48e-07 2.62e-10 8.25 35.2 71.1 260 2457 1173 4632 2.07e+04 3.24e+04 4.22e+04 strong moderate moderate strong weak moderate moderate 6.19 6.13 5.87 6.24 5.23 5.04 5.3 6.34 88.6
28 IgG1 6 3.3e-10 5.22e-10 1.23e-08 1.26e-10 0.512 1.96 3.96 755.0 1400.0 1760.0 308.0 190 815 398 897 3.19e+03 4.68e+03 5.85e+03 0.0 strong moderate moderate strong weak moderate moderate 6.36 6.3 6.02 6.42 5.63 5.9 5.61 6.55 100.0
29 IgG1 4.33e-10 3.5e-10 3.99e-07 1020.0 1520.0 1750.0 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 moderate weak weak strong weak moderate weak 6.24 6.18 5.89 6.2 4.64 4.74 5.15 6.16
30 IgG1 2 3.21e-11 5.94e-12 4.1e-09 2.73e-06 0.00887 0.0268 0.0507 518.0 1650.0 47.1 113.0 200.0 2 6 >25000 >25000 2.75e+01 5.23e+01 7.61e+01 30.0 strong strong strong moderate moderate moderate moderate 6.36 6.3 6.02 6.45 5.72 6.06 5.53 6.59 100.0 E484A
31 IgG1 4 1.42e-10 8.08e-11 7.02e-08 3.96e-10 11.4 80.3 233.0 949 2233 1.21e+04 4.33e+04 9.12e+04 strong weak moderate moderate moderate moderate moderate 6.3 6.26 5.97 6.4 5.68 6.03 5.67 6.6 99.0
32 IgG1 2 5.76e-11 1.85e-11 1.76e-09 1.96e-06 2.04e-10 0.00866 0.0323 0.0664 1.08 1.06 1.06 2 8 735 2676 6.11e+01 1.44e+02 2.37e+02 strong strong strong moderate moderate moderate weak 6.39 6.32 6.05 6.46 5.72 6.08 5.68 6.61 100.0 G496V|S494L
33 IgG1 3.32e-08 1.63e-08 4.8e-06 79.4 581.0 933.0 5650.0 7400.0 7930.0 18 44 259 637 4.57e+03 6.06e+03 7.14e+03 10.0 strong weak weak weak weak moderate moderate 4.35 4.01 3.81 3.77 3.48 3.94 4.91 5.23 7.6
34 IgG1 2.37e-09 1.74e-09 3.92e-09 0.162 0.453 1.05 1.13 1.12 1.12 201 19356 1.02e+04 2.14e+04 3.30e+04 0.0 moderate moderate weak weak weak moderate strong 6.0 5.97 5.52 5.7 4.31 4.12 5.01 5.71 6.4
35 IgG1 7 1.68e-09 1.05e-09 2.81e-09 4.34e-10 259.0 454.0 662.0 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 strong strong moderate weak weak moderate weak 6.21 6.2 5.9 6.25 5.33 5.21 5.31 6.22 7.1
36 IgG1 4.36e-09 4.96e-09 9.51e-07 0.0862 6.6 38.1 4 14 >25000 >25000 3.07e+01 1.18e+02 2.59e+02 60.0 moderate moderate weak weak weak moderate weak 6.18 6.11 5.87 6.18 5.04 5.07 5.06 6.21 del68-70
37 IgG1 1.9e-08 3.96e-08 2840.0 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 moderate moderate weak weak weak moderate weak 5.19 5.28 4.44 4.15 3.53 3.92 4.86 5.2 3.9
38 IgG 6 1.09e-09 4.54e-10 7.05e-09 1.4e-10 0.297 1.31 2.9 863.0 2170.0 2740.0 376.0 1820.0 2920.0 16 78 41 123 3.45e+02 7.16e+02 1.10e+03 0.0 moderate moderate moderate strong moderate moderate strong 6.35 6.3 6.01 6.42 5.52 5.76 5.48 6.45 99.3
39 IgG 2 3.12e-11 1.06e-11 1.78e-09 1.66e-06 3.33e-08 0.00711 0.0201 0.0358 124.0 333.0 750.0 <0.32 <0.32 12500 12500 1.66e+01 2.68e+01 3.56e+01 40.0 strong strong strong strong moderate moderate moderate 6.36 6.32 6.03 6.47 5.71 6.01 5.7 6.61 100.0 L452P
40 IgG 2 7.15e-11 3.82e-11 1.68e-08 6.92e-09 0.248 0.825 1.59 289.0 1540.0 3400.0 76 216 >25000 >25000 4.76e+02 1.46e+03 2.80e+03 0.0 strong moderate strong strong weak moderate moderate 6.37 6.31 6.03 6.45 5.71 6.06 5.82 6.63 100.0 F490C|F490L|F490V
41 IgG1 2.33e-10 2.49e-10 2.75e-08 1.06e-10 6.45 23.2 47.9 5997 >25000 2.50e+04 2.50e+04 2.50e+04 strong weak moderate moderate weak moderate weak 6.3 6.25 5.95 6.35 5.51 5.6 4.6 6.36
42 IgG1 2 4.84e-10 1.59e-10 1.1e-08 4.47e-10 0.0576 0.185 0.348 1000.0 21700.0 53500.0 13.8 53.8 124.0 14 44 2246 6637 7.81e+02 1.81e+03 2.95e+03 0.0 strong moderate strong moderate moderate moderate moderate 6.37 6.3 6.02 6.45 5.61 5.87 5.44 6.56 98.8
43 IgG4 2 1.94e-10 9.59e-11 2.27e-08 1.48e-08 0.0341 0.109 0.21 3.2 17.5 47.5 13 31 1672 3234 1.22e+03 2.06e+03 2.81e+03 10.0 strong weak moderate weak weak moderate moderate 6.38 6.11 6.01 3.8 5.72 4.02 4.25 4.98 100.0
44 IgG1 2 1.42e-10 1.98e-10 4.74e-08 0.0534 0.163 0.302 102.0 265.0 432.0 5 19 >25000 >25000 4.26e+02 1.01e+03 1.66e+03 30.0 strong moderate moderate moderate weak moderate weak 6.3 6.24 5.98 6.4 5.61 5.94 5.57 6.53 100.0
45 IgG4 2 1.7e-10 3.6e-11 3.67e-08 0.00806 0.0277 0.0552 5.47 28.6 68.7 2 8 >25000 >25000 1.04e+02 1.56e+02 1.98e+02 20.0 moderate weak moderate weak weak moderate weak 6.37 6.2 6.02 3.82 5.69 4.03 4.29 5.44 100.0
46 IgG1 2.98e-09 2230.0 3430.0 3800.0 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak moderate weak weak weak moderate weak 4.14 3.92 3.84 3.72 3.5 3.9 4.85 5.39 6.5
47 IgG4 2.73e-09 3.18e-09 4.61 11.0 18.9 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak moderate weak weak weak moderate weak 4.54 4.86 3.98 4.25 3.69 3.92 4.85 4.63 24.4 T588A
48 IgG1 2 4.28e-10 1.51e-10 1.22e-07 2.19e-08 1.15 3.62 13.3 115.0 696.0 426 1028 2.82e+03 4.63e+03 6.18e+03 moderate moderate weak weak weak moderate weak 6.22 6.17 5.86 6.22 4.61 4.46 5.02 6.13 100.0
49 IgG4 2 3.41e-10 1.36e-10 1.48e-07 1.39e-08 0.0574 0.219 0.506 2540.0 3720.0 4100.0 35.7 133.0 259.0 110 256 2.24e+03 9.30e+03 2.14e+04 0.0 moderate moderate moderate weak weak weak weak 6.13 5.75 5.88 3.74 5.57 3.98 4.58 4.61 100.0
50 IgG1 2 4.68e-10 1.75e-10 7.87e-08 1.89e-08 0.869 3.11 6.47 116.0 398.0 1480.0 70 322 >25000 >25000 4.58e+03 1.11e+04 1.87e+04 strong weak moderate strong weak moderate moderate 6.23 6.19 5.86 6.21 4.63 4.58 5.14 6.12 100.0 K417E
51 IgG1 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak weak weak strong weak moderate strong 4.48 3.87 3.79 3.72 3.46 3.94 4.92 4.72 13.5
52 IgG1 2 2.47e-10 1.57e-10 1.71e-09 6.94e-09 0.221 0.606 1.08 134.0 471.0 739.0 64 187 >25000 >25000 6.07e+02 1.49e+03 2.52e+03 strong moderate strong strong moderate moderate moderate 6.36 6.29 6.02 6.44 5.65 5.87 5.41 6.56 95.0 Y489H
53 IgG1 6e-10 0.189 0.801 1.73 34.7 185.0 524.0 86.5 559.0 1130.0 95 242 249 800 5.91e+03 9.09e+03 1.17e+04 0.0 moderate weak weak strong weak moderate moderate 5.45 5.44 4.8 4.96 3.5 3.92 4.86 5.19 70.0
54 7 8.65e-10 2.44e-09 2.44e-07 8.76e-11 0.037 0.0874 0.139 26.4 68.2 111.0 12.9 37.8 64.4 6 22 2 6 2.44e+02 3.44e+02 4.21e+02 weak weak weak moderate weak moderate weak 4.19 3.75 3.86 3.74 3.47 3.9 4.94 4.6 99.5 S375F|S375F,D1118H
55 IgG1 7 1.56e-10 5.8e-11 1.15e-07 3.12e-11 0.0131 0.0383 0.0707 5.98 23.0 48.2 5.47 17.0 30.6 13 27 60 125 2.49e+02 3.85e+02 4.97e+02 0.0 strong moderate moderate strong moderate moderate strong 6.37 6.28 6.01 6.42 5.59 5.74 5.53 6.45 100.0
56 IgG1 7 1.13e-10 3.82e-11 9.42e-08 1.64e-05 3e-11 0.00636 0.0243 0.0517 1.52 6.68 16.5 1.74 5.53 10.5 2 7 6 20 1.02e+02 1.77e+02 2.44e+02 0.0 strong weak moderate strong weak moderate moderate 6.33 6.23 5.96 6.34 5.41 5.27 5.34 6.32 100.0
57 1.36e-09 2.28e-09 2.04e-07 1.53e-10 0.0102 0.0261 0.0453 1.06 3.54 7.11 3.08 9.16 17.7 1 5 3 13 5.15e+01 1.21e+02 1.99e+02 92.7
58 IgG1 7 2.98e-09 9.59e-10 1.39e-07 5.68e-11 0.0046 0.0136 0.0247 0.805 3.1 6.51 0.45 1.74 3.19 5 16 14 27 8.74e+01 1.11e+02 1.27e+02 strong moderate weak strong weak weak weak 5.29 5.52 3.75 3.65 4.13 4.15 5.41 5.29 100.0
59 7 4.76e-10 1.2e-09 2.01e-07 7.63e-11 0.0037 0.0118 0.0225 1.24 4.07 9.24 2.75 10.4 17.7 1 1 <0.32 4 8.90e+01 1.16e+02 1.35e+02 weak weak weak weak weak moderate weak 3.98 3.75 3.8 3.73 3.46 3.9 4.83 4.7 99.4 S371F
60 0.45 2 0.37 2 1.34e+01 2.07e+01 2.66e+01
61 7 6.2e-10 1.3e-09 1.95e-07 5.25e-11 0.00496 0.0158 0.0308 0.886 4.0 10.2 2.28 8.63 18.5 2 5 <0.32 3 9.05e+01 1.32e+02 1.65e+02 weak moderate weak weak weak moderate weak 4.04 3.78 3.78 3.7 3.46 3.91 4.9 4.86 99.5 D442A
62 IgG1 7 2.04e-10 4.77e-11 6.38e-08 1.61e-05 3.55e-11 0.00846 0.0345 0.0743 4.14 14.1 27.5 7.96 26.0 49.2 4 8 4 15 1.84e+02 3.76e+02 5.71e+02 0.0 moderate strong moderate strong weak moderate moderate 6.32 6.24 5.97 6.36 5.41 5.04 5.32 6.29 100.0
63 7 4.52e-10 1.07e-09 1.85e-07 6.04e-11 0.00275 0.0108 0.0234 4.05 11.0 19.1 <0.32 1 <0.32 0.48 1.64e+01 3.65e+01 5.84e+01 weak moderate weak weak weak moderate weak 4.36 3.83 3.78 3.73 3.47 3.93 4.93 4.43 99.8 Y508H
64 7 7.08e-10 1.3e-09 1.69e-07 1.34e-10 0.0116 0.0246 0.0392 25.5 68.3 93.9 2.53 10.3 20.1 3 13 <0.32 4 6.20e+01 8.84e+01 1.09e+02 weak moderate weak weak weak moderate weak 3.94 3.8 3.82 3.73 3.46 3.92 4.86 4.41 96.6 del374,Y508H|del374,D571G
65 IgG1 7 1.01e-10 4.01e-11 5.1e-08 2.84e-11 0.0108 0.0292 0.0511 1.01 5.96 11.1 3.02 10.4 21.1 16 26 18 36 2.50e+02 4.05e+02 5.37e+02 moderate weak moderate strong weak moderate moderate 6.32 6.27 5.97 6.42 5.65 5.77 5.61 6.48 100.0 K417E
66 5.89e-10 1.14e-09 1.4e-07 1.29e-10 0.00417 0.011 0.0195 4.47 15.2 31.9 8.61 26.7 49.6 1 3 <0.32 4 1.12e+02 3.10e+02 5.62e+02 weak weak weak strong weak moderate strong 4.28 4.07 3.88 3.85 3.47 3.9 4.94 4.75 100.0
67 IgG1 2 1.39e-09 6.13e-10 2.85e-07 1.81e-10 17.5 42.4 72.6 21.7 419.0 1160.0 3404 12080 1.99e+03 3.49e+03 4.85e+03 0.0 strong weak moderate strong weak moderate moderate 6.19 6.13 5.77 6.15 4.77 4.67 5.22 6.22 100.0
68 IgG1 2 4.3e-11 3.61e-11 2.89e-09 2.82e-07 2.05e-09 0.00983 0.0258 0.0438 10.3 30.1 54.8 1 1 >25000 >25000 5.93e+01 8.74e+01 1.10e+02 0.0 strong strong strong strong moderate moderate strong 6.39 6.33 6.03 6.46 5.73 6.14 5.91 6.59 100.0
69 IgG1 1 1.36e-09 2.2e-10 2.67e-08 7.05e-11 6.84 20.2 35.4 262.0 558.0 1730.0 2320.0 482 2470 2.50e+04 2.50e+04 2.50e+04 strong moderate moderate moderate weak moderate strong 6.32 6.26 5.99 6.41 5.61 5.88 5.28 6.56 74.1
70 6 2.62e-09 3.79e-09 1.3e-07 6.34e-09 0.606 3.82 9.9 4929 19977 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak weak weak moderate weak weak weak 4.21 3.9 3.89 3.75 3.48 3.93 5.0 4.72 86.9
71 6 2.51e-09 1.27e-09 1.29e-07 5.91e-10 0.876 5.81 18.2 18221 >25000 >12500 >12500 2.50e+04 2.50e+04 2.50e+04 weak weak moderate moderate weak moderate moderate 4.2 3.87 3.85 5.34 3.47 3.92 5.02 4.72 90.1
72 2 2.8e-09 3.72e-09 3.14e-08 5.65e-09 0.137 0.536 1.11 189.0 913.0 2190.0 362 898 >12500 >12500 5.20e+02 1.01e+03 1.48e+03 weak moderate moderate weak weak moderate moderate 4.16 3.81 3.82 3.72 3.48 3.91 4.81 4.43 98.8
73 2 2.85e-09 4.54e-09 2.49e-08 6.99e-09 0.302 1.46 3.27 364 1119 >12500 >12500 3.13e+03 5.68e+03 8.04e+03 weak weak weak weak weak moderate moderate 4.21 4.07 3.87 3.72 3.47 3.95 4.95 4.63 100.0
74 IgG1 3 5.52e-10 2.73e-10 3.42e-08 1.44e-10 0.0782 2.6 9.56 78 543 44 220 1.55e+03 3.63e+03 5.96e+03 0.0 strong strong moderate weak weak moderate strong 6.22 6.18 5.9 6.27 5.25 4.99 5.28 6.37 96.2
75 IgG1 3 2.49e-09 1.18e-09 1.27e-07 3.92e-10 9.65 35.2 760.0 379 3034 689 3668 2.50e+04 2.50e+04 2.50e+04 moderate strong moderate weak weak moderate moderate 6.13 6.1 5.8 6.2 5.09 4.88 5.15 6.25 91.3
76 IgG1 3 3.62e-09 1.46e-09 1.77e-07 9.63e-10 17.6 110.0 502.0 3548 11060 2214 10897 2.50e+04 2.50e+04 moderate moderate moderate weak weak moderate weak 5.99 6.03 5.71 6.08 4.5 4.42 5.13 6.11 92.6
77 IgG1 3 4.34e-09 1.79e-09 3.86e-07 1.07e-09 24.6 833.0 1010.0 1070.0 2.50e+04 2.50e+04 2.50e+04 moderate weak moderate strong weak moderate moderate 5.83 5.82 5.25 5.54 3.5 3.94 4.89 5.53 78.3
78 IgG1 5 7.18e-10 1.87e-10 3.93e-07 1.35e-10 0.0742 0.224 0.663 44.9 164.0 519.0 12 44 10 33 4.61e+01 8.75e+02 4.90e+03 100.0 strong weak moderate strong weak moderate moderate 6.23 6.21 5.91 6.32 5.5 5.57 5.57 6.44 48.7 del68-69,V70I
79 IgG1 2 8.78e-11 6.21e-11 7.45e-10 2.89e-07 3.51e-10 0.0537 0.14 0.235 315.0 39.1 80.6 129.0 0.38 3 379 747 2.38e+01 1.76e+02 5.68e+02 10.0 strong strong strong strong moderate moderate moderate 6.36 6.3 6.02 6.43 5.64 5.9 5.43 6.55 99.1
80 IgG1 3 2.18e-09 1.21e-09 1.04e-07 5.09e-10 0.792 3.34 7.6 371.0 3670.0 232.0 1270.0 222 1595 978 3872 3.58e+03 8.52e+03 1.42e+04 strong moderate moderate strong weak moderate moderate 6.17 6.18 5.88 6.27 5.45 5.36 5.37 6.37 93.7
81 IgG1 3 1.47e-09 8.4e-10 9.88e-08 1.52e-10 0.824 4.14 9.95 1390.0 70900.0 213000.0 227.0 100 627 268 736 4.31e+03 1.24e+04 2.30e+04 0.0 strong moderate moderate moderate weak moderate weak 6.19 6.13 5.85 6.24 5.28 5.16 5.26 6.3 86.8
82 IgG1 7 1.28e-09 1.9e-09 3.61e-08 1.02e-09 86.5 1950.0 3020.0 3360.0 20205 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 strong weak weak weak weak moderate moderate 6.04 6.01 5.61 5.94 4.02 4.12 5.03 5.8 33.1
83 7 3.73e-10 2.14e-10 8.94e-08 6.75e-11 1.03 3.2 6.03 335.0 1140.0 1700.0 380.0 99 396 172 503 2.50e+03 2.90e+03 3.16e+03 10.0 strong weak moderate moderate weak moderate moderate 6.3 6.22 5.94 6.28 5.04 5.1 5.29 6.26 98.0
84 7 4.33e-10 2.78e-10 9.29e-08 6.99e-11 1.57 4.38 7.7 374.0 1440.0 2000.0 569.0 2190.0 5470.0 49 175 225 573 1.27e+03 2.07e+03 2.75e+03 strong weak moderate weak weak moderate moderate 6.31 6.23 5.95 6.32 5.04 5.12 5.31 6.31 96.2 E654A|R408G
85 IgG1 3 2.59e-09 8.04e-10 1.51e-07 2.71e-10 284 786 429 1762 9.62e+03 3.59e+04 7.77e+04 strong moderate moderate weak weak moderate moderate 6.07 6.09 5.73 6.12 4.79 4.63 5.28 6.06 93.2
86 IgG1 3 2.16e-09 4.41e-10 1.03e-07 3.15e-10 6.15 27.2 58.4 >25000 >25000 691 4356 1.68e+04 4.58e+04 8.24e+04 moderate moderate moderate weak weak moderate moderate 6.21 6.18 5.92 6.3 5.38 5.42 5.32 6.39 96.8
87 IgG4 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak moderate weak weak weak moderate weak 4.0 3.79 3.62 3.71 3.46 3.9 4.91 4.65 8.2
88 IgG1
89 IgG1 1 1.22e-09 5.64e-10 6.73e-08 1.49e-10 0.536 2.13 4.47 412.0 1450.0 2380.0 82.5 406.0 417 1117 4.46e+03 2.17e+04 5.46e+04 weak moderate weak weak weak moderate moderate 6.07 6.24 5.73 5.62 5.42 3.93 4.13 5.21 60.9
90 IgG1 2 2.93e-10 1.27e-10 1.1e-07 1.86e-09 0.38 1.19 2.11 1040.0 1520.0 1670.0 218 1357 1.89e+03 4.31e+03 6.98e+03 moderate weak moderate strong weak moderate moderate 6.33 6.26 5.97 6.38 5.53 5.74 5.59 6.49 100.0
91 IgG1 4 2.43e-10 5.69e-10 4.69e-09 4.46e-06 6.46e-10 0.327 1.66 4.94 814.0 1220.0 1350.0 66 680 4846 10146 2.50e+04 2.50e+04 2.50e+04 0.0 strong weak strong strong moderate moderate moderate 6.26 6.23 5.91 6.34 5.48 5.57 5.53 6.39 21.7
92 IgG1 2 1.04e-09 5.73e-10 1.96e-07 0.208 0.521 0.918 144 368 5.92e+02 1.03e+03 1.43e+03 strong moderate moderate moderate weak moderate moderate 6.12 6.08 5.8 6.18 3.8 5.13 5.23 6.17 91.2
93 IgG2 1 1.02e-10 2.7e-11 4.31e-10 6.52e-07 2.02e-11 0.0693 0.225 0.407 26.9 89.8 199.0 26.2 70.1 138.0 >25000 >25000 7.05e+01 9.92e+01 1.21e+02 0.0 moderate weak strong strong weak moderate moderate 6.37 6.32 5.99 3.8 5.77 4.36 4.73 4.56 95.4 R685S
94 IgG1 4 1.04e-10 1.1e-10 5.62e-09 4.35e-11 0.0352 0.0968 0.167 16.2 42.7 73.1 4 8 2 6 8.87e+01 1.38e+02 1.79e+02 45.0 moderate moderate weak weak weak weak weak 6.18 6.19 5.84 6.08 4.29 4.6 5.42 6.02 98.0
95 IgG1 4 8.41e-11 4.88e-11 2.75e-08 2.51e-10 0.0212 0.0638 0.122 24.2 6.69 3.65 0.34 1 798 14 1.24e+02 3.45e+02 6.26e+02 strong moderate weak weak weak moderate moderate 6.18 6.12 5.69 6.07 4.3 4.49 5.02 6.15 98.8
96 IgG1 5 7.65e-11 5.66e-11 9.22e-08 4.7e-11 0.0213 0.0594 0.112 15.5 78.9 191.0 27.7 114.0 267.0 <0.32 6 0.51 11 5.77e+01 1.76e+02 3.38e+02 moderate weak weak moderate weak moderate strong 6.02 6.18 5.41 6.01 4.99 4.16 5.09 6.24 44.8 G339C
97 IgG1 3 1.31e-11 6.31e-12 4.96e-09 3.41e-06 1.31e-11 0.00635 0.0191 0.0335 6.8 32.1 75.1 3.02 9.83 17.7 <0.32 1 <0.32 6 8.25e+01 1.41e+02 1.93e+02 20.0 100.0
98 IgG1 3 7.35e-11 6.51e-11 3.82e-09 4.23e-11 0.13 0.416 0.764 26.9 131.0 378.0 50.1 169.0 330.0 18 66 2 14 2.89e+02 4.28e+02 5.38e+02 10.0 strong moderate weak strong weak strong moderate 6.07 6.06 5.37 6.06 4.32 4.17 5.07 6.11 98.5
99 IgG1 2 4.03e-11 2.13e-11 2.47e-09 1.42e-06 0.0138 0.0358 0.0601 <0.32 <0.32 1605 3436 8.36e+01 1.51e+02 2.14e+02 10.0 strong moderate moderate moderate weak moderate moderate 6.28 6.16 5.95 6.13 4.96 5.37 5.33 6.22 100.0
100 IgG1 2 1.45e-11 8.37e-12 3.3e-09 1.61e-06 1.44e-11 0.00745 0.0181 0.0297 14.0 65.6 165.0 2.87 10.4 21.8 1 3 9 29 1.82e+01 2.93e+01 3.87e+01 80.0 strong strong moderate moderate weak moderate strong 6.28 6.13 6.05 6.19 5.07 5.56 5.21 6.27 100.0
101 IgG1 4 2.99e-11 2.26e-11 3.94e-09 2.7e-11 0.0113 0.0277 0.0452 6.3 20.1 36.8 8.52 45.0 96.2 6 21 9 22 9.78e+01 2.27e+02 3.72e+02 90.0 strong moderate weak moderate weak strong strong 6.26 6.19 6.02 6.11 5.09 5.68 5.58 6.27 100.0 S494L
102 2 1.43e-10 6.77e-11 1.45e-09 4.98e-07 3.59e-11 0.00578 0.0158 0.027 4.47 10.6 17.1 2.81 7.3 10.2 <0.32 <0.32 <0.32 <0.32 2.16e+00 1.06e+01 2.67e+01 0.0 weak weak weak weak weak weak weak 3.84 3.91 3.64 3.33 4.22 3.8 4.63 4.25 84.3
103 2 8.34e-11 1.22e-10 1.62e-09 4.77e-07 5.37e-11 0.00882 0.0244 0.0426 20.0 13.6 26.1 <0.32 <0.32 <0.32 <0.32 2.17e+01 4.28e+01 6.38e+01 weak weak weak weak weak weak weak 3.83 3.71 3.62 3.36 4.17 3.76 4.69 4.27 84.9
104 2 9.36e-11 8.39e-11 1.37e-09 6.74e-11 5.15e-10 0.0168 0.0262 0.0338 60.2 204.0 444.0 264.0 631.0 1060.0 <0.32 <0.32 3 7 4.42e+00 6.57e+00 8.28e+00 weak weak weak weak moderate weak weak 3.8 3.74 3.63 3.33 4.22 3.78 4.78 4.24 86.1
105 IgG1 2 2.15e-11 1.26e-11 1.62e-08 5.44e-10 0.335 0.876 1.52 23 68 >25000 >25000 1.86e+02 1.95e+02 2.00e+02 moderate moderate moderate moderate weak moderate weak 6.27 6.19 6.01 6.14 4.36 5.63 5.38 6.25 100.0 Q493H,R685S
106 IgG1 2 1.3e-11 6.62e-12 9.24e-10 2.79e-07 3.66e-10 0.00685 0.0184 0.0313 <0.32 2 864 2686 1.34e+00 2.12e+00 2.78e+00 moderate strong moderate weak weak weak weak 6.3 6.14 5.99 6.19 4.82 5.55 5.42 6.25 100.0 S494L
107 IgG1 2 2.23e-11 1e-11 9.39e-10 2.26e-07 3.61e-10 0.0082 0.0289 0.054 <0.32 1 302 889 2.02e+01 2.78e+01 3.36e+01 30.0 strong strong moderate moderate weak moderate moderate 6.31 6.22 6.07 6.18 5.19 5.62 5.41 6.27 100.0 E406D,S494P
108 IgG1 2 2.28e-11 1.09e-11 1.04e-09 3.6e-07 4.66e-10 0.0123 0.0351 0.0626 2 5 4915 25000 2.55e+01 4.70e+01 6.73e+01 30.0 strong strong moderate strong weak moderate moderate 6.3 6.18 6.02 6.22 5.08 5.66 5.28 6.26 100.0 R685S
109 IgG1 2 1.63e-11 1.06e-11 5.8e-10 1.96e-07 3.86e-10 0.0145 0.0325 0.0514 1 1 5666 18558 1.88e+01 2.58e+01 3.10e+01 strong strong moderate strong weak moderate strong 6.27 6.16 5.99 6.1 4.65 5.41 5.22 6.25 100.0
110 IgG1 2 2.26e-11 7.08e-12 1.53e-09 7.53e-07 6.18e-10 0.018 0.0495 0.0886 2000.0 2040.0 2050.0 2 6 19149 >25000 1.91e+01 3.97e+01 6.10e+01 strong moderate moderate strong weak strong strong 6.3 6.23 6.09 6.18 5.06 5.58 5.3 6.28 100.0
111 IgG1 2 2.02e-11 1.01e-11 1.39e-09 3.84e-07 3.94e-10 0.0173 0.044 0.0742 15 31 16200 >25000 6.71e+01 8.75e+01 1.02e+02 0.0 strong moderate moderate strong weak strong strong 6.29 6.2 6.07 6.19 5.01 5.6 5.5 6.29 100.0
112 IgG1 2 1.78e-11 9.16e-12 3.46e-10 1.23e-07 3.09e-10 0.0101 0.0264 0.0442 0.976 3 14 8465 23584 2.53e+01 3.77e+01 4.76e+01 10.0 moderate strong moderate strong weak strong strong 6.25 6.18 6.01 6.12 4.88 5.5 5.38 6.27 100.0 S494P|S494L
113 IgG1 7 3.71e-10 2.5e-10 1.37e-09 1.48e-10 9.75 30.3 54.3 2140.0 5390.0 8490.0 3580.0 9210.0 11700.0 1846 6065 2.50e+04 2.50e+04 2.50e+04 moderate moderate weak strong weak moderate moderate 6.06 6.11 5.48 6.03 4.35 4.54 4.12 6.09 27.2
114 IgG1 7 3.53e-10 2.21e-10 6.2e-10 7.49e-08 1.25e-10 2.66 8.58 15.7 1290.0 5380.0 7560.0 120 1435 2.50e+04 2.50e+04 2.50e+04 moderate moderate moderate moderate weak moderate moderate 6.0 6.01 5.28 5.98 4.26 4.28 4.85 6.05 31.1
115 IgG1 7 3.79e-10 2.43e-10 8.54e-10 3.57e-07 2.19e-10 3.41 11.6 21.2 965 2939 1.32e+04 2.78e+04 4.30e+04 moderate moderate moderate strong weak moderate moderate 6.05 6.06 5.27 6.0 4.28 4.45 4.83 6.07 34.5
116 IgG1 5 9.11e-11 5.41e-11 1.03e-08 3.47e-11 0.00943 0.027 0.0474 8.93 27.9 45.6 8.91 19.9 29.9 2 5 <0.32 <0.32 5.26e+01 7.77e+01 9.76e+01 90.0 moderate moderate strong strong weak weak moderate 6.03 5.87 5.47 5.9 4.25 4.37 4.92 6.03 29.2 G339V|G339C|G339F
117 IgG1 4 1.29e-11 6.38e-12 9.06e-10 2.88e-07 3.53e-11 0.00732 0.0169 0.0273 561.0 2520.0 6210.0 7030.0 32600.0 62000.0 2 7 0.5 16 1.29e+01 1.51e+01 1.66e+01 80.0 moderate weak moderate weak moderate strong moderate 6.35 6.21 6.23 6.14 6.48 6.06 5.66 6.33 64.6
118 IgG1 0.173 0.415 0.71 102.0 622.0 1190.0 63 173 542 1823 2.24e+02 3.87e+02 5.32e+02 60.0 moderate strong moderate weak weak moderate moderate 6.31 6.12 6.15 6.18 5.28 5.88 5.8 6.32 100.0 S371F
119 7 1.16e-09 4.52e-10 1.79e-07 5.71e-11 0.00269 0.0087 0.0165 0.907 3.5 8.08 2.03 6.23 12.7 <0.32 3 <0.32 4 1.71e+01 2.28e+01 2.70e+01 weak weak weak weak moderate weak weak 3.89 3.69 3.65 3.57 3.82 3.93 5.44 4.39 100.0
120
121 7 1.06e-09 4.29e-10 1.95e-07 3.75e-11 0.0022 0.00802 0.0161 0.637 2.13 3.93 0.431 2.34 5.71 <0.32 <0.32 0.64 2 1.79e+01 3.82e+01 5.96e+01 weak weak weak strong weak weak weak 3.87 3.67 3.68 3.58 3.81 3.95 4.81 4.38 99.5
122 7 9.01e-10 6.01e-10 2.03e-07 4.09e-11 0.0021 0.00732 0.0144 1.31 5.67 12.6 1.09 3.74 7.89 2 8 <0.32 3 3.98e+01 1.44e+02 3.06e+02 weak weak weak weak weak weak weak 3.84 3.7 3.67 3.61 3.81 3.95 4.85 4.36 97.9
123 7 1.33e-09 4.06e-10 2.06e-07 3.68e-11 0.00108 0.00317 0.00597 0.51 1.74 3.55 0.179 0.731 1.46 <0.32 <0.32 <0.32 0.96 1.82e+01 1.17e+02 3.49e+02 weak weak weak weak weak moderate weak 3.88 3.71 3.67 3.58 3.84 3.94 5.14 4.37 97.6
124 7 9.46e-10 5.39e-10 1.67e-07 3.76e-11 0.000893 0.00282 0.00531 0.678 2.69 5.87 0.631 2.14 4.16 <0.32 0.92 <0.16 <0.16 1.82e+01 3.46e+01 5.02e+01 0.0 weak weak weak weak weak weak weak 3.88 3.7 3.69 3.57 3.81 3.93 5.59 4.39 98.3
125 7 1.6e-09 4.99e-10 1.84e-07 6.42e-11 0.00202 0.00644 0.0121 1.93 4.88 8.89 1.76 6.76 14.2 1 1 <0.32 5 4.12e+01 4.52e+01 4.77e+01 weak weak weak strong weak moderate weak 3.86 3.68 3.65 3.56 3.83 3.94 5.52 4.42 98.8
126 7 9.42e-10 3.95e-10 1.39e-07 6.06e-11 0.00202 0.00634 0.0119 1.92 7.37 15.4 0.245 7.11 23.0 0.35 1 <0.32 0.84 1.97e+01 6.74e+01 1.39e+02 weak weak weak moderate weak weak weak 3.85 3.69 3.65 3.56 3.81 3.94 5.44 4.46 98.5
127 IgG1 7 1.81e-09 9.03e-10 1.06e-07 5.01e-11 0.00277 0.0108 0.023 85000.0 3240000.0 8310000.0 1.92 7.64 16.7 1 2 0.34 3 4.04e+01 4.60e+01 4.97e+01 0.0 strong moderate weak moderate moderate strong moderate 5.96 5.95 5.57 5.96 5.64 4.28 5.77 5.88 98.6
128 IgG1 7 3.6e-09 1.37e-09 1.19e-07 7.74e-11 0.00558 0.0183 0.0344 2.66 11.2 22.8 2.84 9.37 19.3 7.41e+01 1.09e+02 1.37e+02 0.0 strong moderate weak weak weak strong moderate 6.17 6.1 5.71 6.11 5.95 5.11 5.05 6.12 98.6
129 7 1.25e-09 6.49e-10 1.35e-07 5.38e-11 0.00198 0.00746 0.0159 1.59 5.95 12.3 0.936 2.98 4.85 <0.32 1 8 17 3.36e+01 7.58e+01 1.22e+02 0.0 weak weak weak moderate weak weak weak 3.86 3.7 3.67 3.66 3.82 3.93 5.8 4.36 99.6
130 <0.32 <0.32 <0.16 <0.16
131 IgG 7 1.01e-09 3.78e-10 2.05e-09 9.09e-07 3.97e-10 13.6 33.5 55.3 -53.0 -53.0 -53.0 6560.0 11100.0 12700.0 1550 9937 2.50e+04 2.50e+04 2.50e+04 moderate moderate weak weak weak strong weak 6.15 6.09 5.66 6.01 3.82 3.94 4.85 6.17 14.6
132 IgG 9.83e-10 5.63e-10 2.18e-10 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 moderate moderate moderate moderate moderate weak weak 5.84 5.85 5.25 5.67 3.83 3.93 4.82 5.87 2.5
133 IgG 7.08e-10 1.23e-09 3.12e-08 1.12e-09 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 moderate moderate strong strong weak weak moderate 6.21 6.19 5.91 6.18 3.86 3.93 4.81 6.24 5.5
134 IgG 5 6.75e-10 3.5e-10 9e-08 3.66e-11 0.0482 0.161 0.317 22.9 79.8 162.0 21.4 61.7 110.0 16 48 11 69 1.90e+02 2.07e+02 2.18e+02 70.0 strong strong moderate strong weak moderate moderate 6.11 6.04 5.79 6.06 5.76 5.01 4.73 6.12 63.5
135 IgG >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 weak weak moderate strong weak weak weak 3.84 3.69 3.71 3.58 3.83 3.95 4.68 4.29 6.5
136 IgG 2 6.68e-10 3.33e-10 9.86e-09 3.44e-06 6.13e-09 0.0777 0.231 0.427 20.4