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CoVIC ID
Antibody features 		Affinity, KD (M) Pseudovirus neutralization (µg/mL) Authentic virus neutralization (µg/mL) In vivo protection survival (%) Fc Activity Complex formation inhibition (%) sequence / structural features Details
Isotype Competition bin Full-length ectodomain D614 Full-length ectodomain D614G RBD NTD IC501best ordering: ascending IC801best ordering: ascending IC901best ordering: ascending IC502best ordering: ascending IC802best ordering: ascending IC902best ordering: ascending K18 mice hamsters Phagocytosis Complement Deposition NK activation FcR binding Spike: ACE2 Escape Structure
1 IgG1 2.24e-09 2.57e-10 1.46e-06 1.83 6.37 14.1 69.64
2 IgG1 1.71e-10 7.6e-11 1.23e-07 1.47 4.01 7.91 100.0
3 IgG1 2.03e-09 1.22e-09 8.93e-07 2.32 8.36 16.0 90.31
4 IgG1 3.34e-10 1.19e-10 1.11e-07 0.709 2.48 5.02 100.0
5 IgG1 1.49e-09 1.27e-09 3.98e-07 0.853 2.6 5.26 98.2
6 IgG1 3.06e-10 1.23e-10 1.05e-08 36.3 74.9 118.0 100.0
7 IgG1 1.16e-09 1.49e-09 3.92e-08 0.0538 0.146 0.261 93.93
8 IgG1 9.31e-10 6.64e-10 2.36e-08 12.8 26.0 40.9 97.95
9 IgG1 2.28e-11 1.04e-11 2.33e-10 9.29e-08 0.013 0.024 0.034 100.0
10 IgG1 2.53e-11 1.22e-11 2.04e-10 8.55e-08 0.01 0.021 0.033 100.0
11 IgG1 3.25e-11 1.45e-11 2.11e-10 4.67e-08 0.006 0.016 0.028 99.45
12 IgG1 1.53e-11 7.46e-12 1.64e-10 7.55e-08 0.007 0.019 0.031 100.0
13 IgG1 1.23e-11 6.94e-12 1.16e-10 5.11e-08 0.006 0.015 0.025 100.0
14 IgG1 6.11e-11 1.62e-11 1.94e-09 1.14e-06 0.01 0.025 0.043 100.0
15 IgG1 1.3e-10 6.74e-11 1.19e-08 1.19e-07 0.032 0.107 0.223 100.0
16 IgG1 2.16e-10 7.42e-11 5.31e-09 1.03e-06 0.045 0.18 0.388 100.0
17 IgG1 6.94e-10 5.9e-10 3.46e-08 1.03 3.02 5.63 66.97
18 IgG
19 IgG 1.45e-09 1.68e-09 2.64e-08 23.66
20 IgG1 1.05e-09 1.2e-09 8.15e-08 0.072 0.587 8.96
21 IgG1 6.93e-10 2.06e-09 2.08e-10 12.5 46.6 100.0 11.58
22 IgG1 1.49e-09 4.41e-09 1.04e-07 128.0 379.0 648.0 51.13
23 IgG1 5.14e-10 8.61e-10 7.13e-08 14.2 52.1 105.0 36.3
24 IgG1 1.66e-09 3.39e-09 1.46e-08 142.0 48.67
25 IgG1 1.48e-09 2.79e-09 8.49e-08 324.0 687.0 829.0 31.16
26 IgG1 9.07e-10 1.74e-09 3.88e-08 31.83
27 IgG1 4.95e-09 2.09e-09 1.48e-07 8.25 35.2 71.1 88.62
28 IgG1 4.56e-10 7.68e-10 1.23e-08 0.512 1.96 3.96 100.0
29 IgG1 5.97e-10 5.17e-10 3.99e-07
30 IgG1 4.43e-11 8.75e-12 4.1e-09 2.73e-06 0.009 0.027 0.051 100.0
31 IgG1 1.96e-10 1.19e-10 7.02e-08 11.4 80.3 233.0 99.04
32 IgG1 7.94e-11 2.72e-11 1.76e-09 1.96e-06 0.009 0.032 0.066 100.0
33 IgG1 4.59e-08 2.4e-08 4.8e-06 79.4 581.0 933.0 7.62
34 IgG1 3.26e-09 2.57e-09 0.162 0.453 1.05 6.38
35 IgG1 2.32e-09 1.54e-09 2.81e-09 259.0 454.0 662.0 7.07
36 IgG1 6.01e-09 7.29e-09 9.51e-07 0.13 8.5 43.6
37 IgG1 2.62e-08 5.82e-08 2840.0 3.88
38 IgG 1.5e-09 6.7e-10 7.05e-09 0.297 1.31 2.9 99.27
39 IgG 4.3e-11 1.57e-11 1.78e-09 1.66e-06 0.007 0.02 0.036 100.0
40 IgG 9.87e-11 5.63e-11 1.68e-08 0.248 0.825 1.59 100.0
41 IgG1 3.21e-10 3.67e-10 2.75e-08 6.45 23.2 47.9
42 IgG1 6.67e-10 2.35e-10 1.1e-08 0.058 0.185 0.348 98.8
43 IgG4 2.67e-10 1.41e-10 2.27e-08 0.034 0.109 0.21 100.0
44 IgG1 1.96e-10 2.91e-10 4.74e-08 0.0534 0.163 0.302 100.0
45 IgG4 2.34e-10 5.3e-11 3.67e-08 0.00806 0.0277 0.0552 100.0
46 IgG1 4.24e-09 6.52
47 IgG4 3.77e-09 4.68e-09 4.61 10.9 18.9 24.41
48 IgG1 5.72e-10 2.16e-10 1.22e-07 1.15 3.62 13.3 100.0
49 IgG4 4.55e-10 1.94e-10 1.48e-07 0.057 0.219 0.506 100.0
50 IgG1 6.25e-10 2.5e-10 7.87e-08 0.869 3.11 6.47 100.0
51 IgG1 13.54
52 IgG1 3.29e-10 2.23e-10 1.71e-09 0.221 0.606 1.08 94.95
53 IgG1 0.189 0.801 1.73 70.0
54 1.15e-09 3.48e-09 2.44e-07 0.037 0.087 0.139 99.48
55 IgG1 2.07e-10 8.26e-11 1.15e-07 0.013 0.038 0.071 100.0
56 IgG1 1.5e-10 5.44e-11 9.42e-08 1.64e-05 0.006 0.024 0.052 100.0
57 1.81e-09 3.25e-09 2.04e-07 0.01 0.026 0.045 92.66
58 IgG1 3.98e-09 1.37e-09 1.39e-07 0.0046 0.0136 0.0247 100.0
59 6.35e-10 1.7e-09 2.01e-07 0.004 0.012 0.023 99.4
60
61 8.25e-10 1.85e-09 1.95e-07 0.005 0.016 0.031 99.46
62 IgG1 2.71e-10 6.8e-11 6.38e-08 1.61e-05 0.008 0.035 0.074 100.0
63 6.03e-10 1.52e-09 1.85e-07 0.003 0.011 0.023 99.84
64 9.44e-10 1.85e-09 1.69e-07 0.012 0.025 0.039 96.6
65 IgG1 1.35e-10 5.71e-11 5.1e-08 0.011 0.029 0.051 100.0
66 7.85e-10 1.63e-09 1.4e-07 0.004 0.011 0.02 100.0
67 IgG1 1.86e-09 8.74e-10 2.85e-07 17.5 42.4 72.6 100.0
68 IgG1 5.72e-11 5.14e-11 2.89e-09 2.82e-07 0.00983 0.0258 0.0438 100.0
69 IgG1 1.82e-09 3.14e-10 2.67e-08 6.84 20.2 35.4 74.07
70 3.5e-09 5.4e-09 1.3e-07 0.606 3.82 9.9 86.89
71 3.35e-09 1.81e-09 1.29e-07 0.876 5.81 18.2 90.07
72 3.73e-09 5.31e-09 3.14e-08 0.137 0.536 1.11 98.77
73 3.8e-09 6.48e-09 2.49e-08 0.302 1.46 3.27 100.0
74 IgG1 7.36e-10 3.89e-10 3.42e-08 0.0782 2.6 9.56 96.23
75 IgG1 3.32e-09 1.69e-09 1.27e-07 9.65 35.2 760.0 91.31
76 IgG1 4.84e-09 2.07e-09 1.77e-07 17.6 110.0 502.0 92.58
77 IgG1 5.8e-09 2.55e-09 3.86e-07 24.6 78.33
78 IgG1 9.57e-10 2.66e-10 3.93e-07 0.0742 0.224 0.663 48.69
79 IgG1 1.17e-10 8.85e-11 7.45e-10 2.89e-07 0.0537 0.14 0.235 99.14
80 IgG1 2.91e-09 1.73e-09 1.04e-07 0.792 3.34 7.6 93.73
81 IgG1 1.96e-09 1.2e-09 9.88e-08 0.824 4.14 9.95 86.84
82 IgG1 1.72e-09 2.71e-09 3.61e-08 86.5 33.07
83 4.97e-10 3.04e-10 8.94e-08 1.03 3.2 6.03 98.04
84 5.76e-10 3.96e-10 9.29e-08 1.57 4.38 7.7 96.17
85 IgG1 3.46e-09 1.14e-09 1.51e-07 93.19
86 IgG1 2.89e-09 6.28e-10 1.03e-07 6.15 27.2 58.4 96.8
87 IgG4 8.23
88 IgG1
89 IgG1 1.62e-09 8.03e-10 6.73e-08 0.536 2.13 4.47 60.9
90 IgG1 3.91e-10 1.81e-10 1.1e-07 0.38 1.19 2.11 100.0
91 IgG1 3.24e-10 8.11e-10 4.69e-09 4.46e-06 0.327 1.66 4.94 21.68
92 IgG1 1.38e-09 8.15e-10 1.96e-07 0.208 0.521 0.918 91.16
93 IgG2 1.36e-10 3.85e-11 4.31e-10 6.52e-07 0.0693 0.225 0.407 95.42
94 IgG1 1.39e-10 1.57e-10 5.62e-09 0.0352 0.0968 0.167 97.97
95 IgG1 1.12e-10 6.95e-11 2.75e-08 0.0212 0.0638 0.122 98.84
96 IgG1 1.02e-10 8.06e-11 9.22e-08 0.0213 0.0594 0.112 44.82
97 IgG1 1.74e-11 8.97e-12 4.96e-09 3.41e-06 0.00635 0.0191 0.0335 100.0
98 IgG1 9.78e-11 9.27e-11 3.82e-09 0.13 0.416 0.764 98.47
99 IgG1 5.36e-11 3.03e-11 2.47e-09 1.42e-06 0.0138 0.0358 0.0601 100.0
100 IgG1 1.93e-11 1.19e-11 3.3e-09 1.61e-06 0.00745 0.0181 0.0297 100.0
101 IgG1 3.99e-11 3.22e-11 3.94e-09 0.0113 0.0277 0.0452 100.0
102 1.91e-10 9.64e-11 1.45e-09 4.98e-07 0.00578 0.0158 0.027 84.3
103 1.11e-10 1.74e-10 1.62e-09 4.77e-07 0.00882 0.0244 0.0426 84.95
104 1.25e-10 1.2e-10 1.37e-09 6.74e-11 0.0168 0.0262 0.0338 86.1
105 IgG1 2.87e-11 1.79e-11 1.62e-08 0.335 0.876 1.52 100.0
106 IgG1 1.73e-11 9.42e-12 9.24e-10 2.79e-07 0.00685 0.0184 0.0313 100.0
107 IgG1 2.98e-11 1.43e-11 9.39e-10 2.26e-07 0.0082 0.0289 0.054 100.0
108 IgG1 3.04e-11 1.56e-11 1.04e-09 3.6e-07 0.0123 0.0351 0.0626 100.0
109 IgG1 2.18e-11 1.51e-11 5.8e-10 1.96e-07 0.0145 0.0325 0.0514 100.0
110 IgG1 3.01e-11 1.01e-11 1.53e-09 7.53e-07 0.018 0.0495 0.0886 100.0
111 IgG1 2.7e-11 1.44e-11 1.39e-09 3.84e-07 0.0173 0.044 0.0742 100.0
112 IgG1 2.37e-11 1.3e-11 3.46e-10 1.23e-07 0.0101 0.0264 0.0442 100.0
113 IgG1 4.96e-10 3.56e-10 1.37e-09 9.75 30.3 54.3 27.19
114 IgG1 4.71e-10 3.16e-10 6.2e-10 7.49e-08 2.66 8.58 15.7 31.07
115 IgG1 5.07e-10 3.47e-10 8.54e-10 3.57e-07 3.41 11.6 21.2 34.53
116 IgG1 1.21e-10 7.71e-11 1.03e-08 0.00943 0.027 0.0474 29.2
117 IgG1 1.72e-11 9.08e-12 9.06e-10 2.88e-07 0.00732 0.0169 0.0273 64.64
118 IgG1 0.173 0.415 0.71 100.0
119 1.56e-09 6.43e-10 1.79e-07 0.00269 0.0087 0.0165 100.0
120
121 1.42e-09 6.12e-10 1.95e-07 0.0022 0.00802 0.0161 99.49
122 1.2e-09 8.56e-10 2.03e-07 0.0021 0.00732 0.0144 97.9
123 1.78e-09 5.78e-10 2.06e-07 0.00108 0.00317 0.00597 97.57
124 1.26e-09 7.68e-10 1.67e-07 0.000893 0.00282 0.00531 98.26
125 2.14e-09 7.11e-10 1.84e-07 0.00202 0.00644 0.0121 98.83
126 1.26e-09 5.63e-10 1.39e-07 0.00202 0.00634 0.0119 98.46
127 IgG1 2.42e-09 1.29e-09 1.06e-07 0.00277 0.0108 0.023 98.61
128 IgG1 4.81e-09 1.95e-09 1.19e-07 0.00558 0.0183 0.0344 98.64
129 1.67e-09 9.25e-10 1.35e-07 0.00198 0.00746 0.0159 99.58
130
131 IgG 1.35e-09 5.38e-10 2.05e-09 9.09e-07 13.6 33.5 55.3 14.58
132 IgG 1.31e-09 8.02e-10 2.54
133 IgG 9.47e-10 1.75e-09 3.12e-08 5.53
134 IgG 8.99e-10 4.98e-10 9e-08 0.0482 0.161 0.317 63.48
135 IgG 6.46
136 IgG 8.9e-10 4.74e-10 9.86e-09 3.44e-06 0.0777 0.231 0.427 99.48
137 IgG 2.46e-09 2.26e-09
138 IgG 5.28e-07 312.0
139 IgG 8.88e-10 3.02e-09 4.46e-08 251.0 63.86
140 IgG 1.8e-10 1.09e-10 1.9e-07 0.181 0.621 1.31 100.0
141 IgG 3.38e-10 1.85e-10 1.07e-07 2.47 9.64 19.8 100.0
142 IgG 3.89e-10 3.99e-10 1.65e-08 0.0874 0.286 0.534 100.0
143 IgG 5.08e-10 3.33e-10 5.91e-09 0.237 0.733 1.66 100.0
144 IgG1 3.26e-10 1.55e-10 1.03e-10 3.21e-07 0.00439 0.0106 0.0175 23.59
145 IgG1 5.97e-10 2.13e-10 3.94e-08 0.0126 0.0526 0.114 99.91
146 IgG1 1.06e-09 8.2e-10 4.67
147 IgG1 2.57e-11 2.88e-11 2.3e-09 1.65e-06 0.00584 0.0146 0.024 100.0
148 IgG1 3.97e-11 1.46e-11 1.85e-09 1.36e-06 0.00382 0.0102 0.017 100.0
149 IgG1 7.91e-11 9.7e-11 2.23e-08 0.0956 0.244 0.401 100.0
150 IgG1 2.79e-09 1.1e-09 1.41e-07 0.331 0.981 1.8 100.0
151 IgG1 5.96e-10 9.67e-10 6.31e-09 2.91e-06 1.31 4.82 9.33 46.24
152 IgG1 4.36e-10 1.95e-09 3.02e-09 1.82e-06 1.75 7.58 17.0 31.24
153 IgG1 6.74e-10 2.05e-10 2.06e-09 6.02e-07 0.0288 0.087 0.157 99.42
154 IgG1 4.47e-10 4.13e-10 0.328 0.807 1.34 2.43
155 IgG1 4.51e-11 1.49e-10 8.42e-10 6.53e-07 0.0115 0.0276 0.0444 99.88
156 IgG1 6.35e-11 4.48e-11 4.46e-10 2.19e-07 0.0231 0.0608 0.103 97.91
157 IgG1 3.59e-10 9.16e-10 6.65e-09 2.32e-06 0.0398 0.101 0.171 98.22
158 IgG1 1.1e-10 8.4e-11 1.59e-09 6.82e-07 0.0325 0.0869 0.15 99.55
159 IgG1 2.21e-10 3.18e-10 2.49e-08 0.0781 0.223 0.399 100.0
160 IgG1 5.02e-10 1.03e-09 1.47e-08 0.0623 0.183 0.335 99.62
161 IgG1 3.11e-09 2.55e-09 6.03e-07 0.0738 0.243 0.977
162 IgG1 2.12e-09 2.39e-09 1.91e-07 43.1 108.0 150.0 96.76
163 IgG1 1.01e-09 4.72e-10 1.62e-07 0.613 2.45 5.1 100.0
164 IgG1 2.3e-10 1.39e-10 2.25e-09 1.05e-06 0.0451 0.132 0.24 97.0
165 IgG1 1.35e-08 6.83e-09 11.1 32.7 57.8
166 IgG1 2.34e-10 1.6e-10 8.26e-10 4.75e-07 0.721 3.99 9.14 32.21
167 IgG1 2.24e-10 1.4e-10 1.87e-09 6.62e-07 0.047 0.129 0.225 99.26
168 IgG1 1.74e-10 3.5e-10 2.41e-08 0.057 0.211 0.392 100.0
169 IgG1 3.42e-10 3.16e-10 3.38e-08 0.0908 0.304 0.588 100.0
170 IgG1 4.8e-10 1.07e-09 1.16e-09 6.6e-07 1.21 5.48 11.9 17.44
171 IgG1 1.53e-10 1.32e-10 42.1 133.0 184.0 4.46
172 IgG1 1.72e-10 4.43e-10 9.47e-09 2.57e-06 3.11 18.4 39.7 33.87
173 IgG1 2.33e-09 1.08e-09 8.45e-08 39.8 201.0
174 IgG 8.34
175 IgG 3.76
176 IgG 6.69
177 IgG 11.18
178 IgG 9.33e-10 7.26e-10 1.49e-07 21.0 91.1 166.0 46.08
179 IgG 6.25e-10 2.68e-10 2.24e-08 0.685 1.95 3.4 100.0
180 IgG 1.43e-09 8.43e-10 9.92e-07 0.772 5.86 21.8 100.0
181 IgG1 1.1e-10 4.6e-11 2.09e-09 1.5e-06 0.0123 0.0266 0.0427 72.36
182 IgG1 1.26e-10 1.49e-10 1.9e-08 0.0122 0.031 0.0522 100.0
183 IgG 4.31e-11 2.43e-11 6.97e-09 1.66e-09 0.0502 0.137 0.229 100.0
184 IgG 5.92e-11 2.87e-11 3.44e-08 0.0439 0.197 0.54 100.0
185 IgG 1.65e-11 1.6e-11 1.23e-08 0.00441 0.0122 0.023 100.0
186 IgG 4.57e-10 1.8e-10 6.1e-09 0.117 0.374 0.671 98.96
187 IgG 2.44e-10 9.6e-11 5.4e-09 19.83
188 IgG 1.86e-08 1.2e-08 7.16e-07 0.404 19.4
189 IgG 3.84e-09 1.44e-09 3.14e-07 0.108 2.97
190 IgG 4.86e-09 2.21e-09 4.07e-07 0.158 3.76
191 IgG 1.9e-09 1.13e-09 1.18e-07 0.0967 1.44
192 IgG 4.4e-11 5.34e-11 9.02e-09 5.67e-09 0.0539 0.0861 0.113 100.0
193 IgG 9.36e-11 2.76e-11 1.06e-08 4.54e-07 0.0683 0.117 0.163 100.0
194 IgG 1.12e-10 6.99e-11 3.73e-08 7.01e-07 0.0472 0.0834 0.117 100.0
195 IgG 3.48e-11 3.99e-11 8.64e-09 8.85e-07 65.4 109.0 147.0 100.0
196 IgG 3.97e-10 2.29e-10 5.51e-07 85.1 162.0 237.0 79.7
197 IgG 1.03e-10 4.99e-11 3.33e-08 7.33e-07 0.029 0.0661 0.104 92.99
198 IgG 5.52e-11 3.82e-11 3.33e-08 1.17e-06 0.061 0.13 0.198 100.0
199 IgG 3.06e-10 2.02e-10 8.33e-09 3.59e-07 0.0734 0.165 0.257 99.01
200 IgG 1.1e-10 3.14e-11 2.19e-08 0.0606 0.182 0.34 100.0
201 IgG 6.02e-11 1.03e-10 2.86e-09 9.75e-07 0.00949 0.0254 0.044 99.73
202 IgG1 5.97e-10 3.34e-10 0.741 2.26 4.38 100.0
203 IgG1 0.0144 0.0465 0.0863
204 IgG1 0.031 0.0794 0.131
205 IgG1 0.0173 0.0501 0.0892
206 IgG1
207 IgG1 0.0762
208 IgG1 0.0626 0.0948 0.126
209 IgG1
210 IgG 0.156
211 IgG1 0.00516 0.0105 0.0159
212 IgG1 0.071 0.152 0.241
213 IgG1 0.0284 0.0898 0.16
214 IgG1 0.338 0.945 1.22
215 IgG1 0.0207 0.0615 0.111
216 IgG1 3.56 8.73 14.3
217 IgG1 0.636 1.35 1.99
218 IgG1 0.3 0.603 0.796
219 IgG1
220 IgG1 65.3 274.0
221 IgG1 0.15
222 IgG1
223 IgG1 0.0394
224 IgG1 48.3 234.0 814.0
225 IgG1
226 IgG1
227 IgG1
228 IgG1
229 IgG1
230 IgG1 2.94 14.3 31.4
231 IgG1 0.0091 0.0249 0.0425
232 IgG1 0.109 0.28 0.469
233 IgG1
234 IgG1 0.222 0.658 1.19
235 IgG1 0.00568 0.016 0.0277
236 IgG1 0.00959 0.0289 0.0513
237 IgG1 0.0372 0.0987 0.165
238 IgG1 0.26 0.81 1.45
239 IgG1 0.0548 0.149 0.264
240 IgG
241 IgG1
242 IgG1
243 IgG1
244 IgG1
245 IgG1
246 IgG1
247 IgG1
248 IgG1
249 IgG1
250 IgG1
251 IgG1
252 IgG1
253 IgG1
254 IgG1
255 IgG1
256 IgG1
257 IgG1
258 IgG1
259 IgG1
260 IgG1
261 IgG1
262 IgG1
263 IgG1
264 IgG1
265 IgG1
266 IgG1
267 IgG1
268 IgG1
269 IgG1

Data last updated: